Office of Technology Commercialization

Low, Philip Stewart

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Innovations

	Innovation Title	Categories	Lead Inventor
	Fibroblast Activation Protein (FAP)-Targeted Antifibrotic Therapy 2021-LOW-69364	Pharmaceuticals	Low, Philip Stewart
	Off-the-shelf Chimeric Antigen Receptor (CAR) NK Cell Production and Application in Cancer Immunotherapy 2022-BAO-69890	Biotechnology Medical/Health	Bao, Xiaoping
	Folate Receptor-Targeted Conjugates for Treatment of Spinal Trauma 2021-LOW-69272	Pharmaceuticals Chemistry and Chemical Analysis	Low, Philip Stewart
	Carbonic Anhydrase IX targeted radioligand therapeutics for hypoxic solid tumors 2022-LOW-69560	Pharmaceuticals	Low, Philip Stewart
	Compounds and Methods for the Selective Rejuvenation of Exhausted CAR T Cells 2022-LOW-69573	Pharmaceuticals	Low, Philip Stewart
	Drug Conjugate for Early Cancer Diagnosis and Reduced Chemotherapy Side Effects 2017-LOW-67871	Chemistry and Chemical Analysis Medical/Health	Low, Philip Stewart
	Design and Synthesis of Fibroblast MULTIVALENT Drugs and Imaging Agents 2019-LOW-68745	Pharmaceuticals Chemistry and Chemical Analysis	Low, Philip Stewart
	Targeted Imaging and Therapy for Cancer using the Fibroblast Activated Proteins (FAP) 2020-LOW-68793	Medical/Health Pharmaceuticals	Low, Philip Stewart
	Small Molecule Ligand for Targeted Influenza Treatment 2018-LOW-68327	Pharmaceuticals	Low, Philip Stewart
	Promising Target in Cancer Therapy 66125	Biotechnology Pharmaceuticals	Low, Philip Stewart
	Targeting T Cells in Tumor Microenvironments through Immunotherapy 2019-LOW-68726	Pharmaceuticals Medical/Health	Low, Philip Stewart
	Bone Fracture Repair by Targeting of Bone Anabolic Agents 2015-LOW-67195	Biomedical Engineering Pharmaceuticals	Low, Philip Stewart
	CAFs are a leading reason for ineffective cancer treatments 2019-LOW-68704	Chemistry and Chemical Analysis Biotechnology	Low, Philip Stewart
	Selective Reprogramming of Pulmonary Macrophages for Treatment of Idiopathic Pulmonary Fibrosis 2019-LOW-68624	Pharmaceuticals	Low, Philip Stewart
	Fibroblast-targeted Drugs and Imaging for Improved Internalization and Retention 2019-LOW-68689	Chemistry and Chemical Analysis	Low, Philip Stewart
	Human Monoclonal Folate Receptor Beta Antibody 65627	Biotechnology Medical/Health	Low, Philip Stewart
	Selective Capture and Identification of Bacteria 65600	Biomedical Engineering Biotechnology	Low, Philip Stewart

Details

Biography	Dr. Philip Low is the Ralph C. Corley Distinguished Professor of Chemistry and the Presidential Scholar for Drug Discovery at Purdue University. Dr. Low earned a B.S. from Brigham Young University and a Ph.D. from the University of California, San Diego. In 2015, Dr. Low received recognition with numerous awards including election to the National Academy of Inventors, the Mathias P. Mertes Award, the Roland T. Lakey Award, and the American Association for Cancer Research (AACR) Award for Outstanding Achievement in Chemistry in Cancer Research. Dr. Low received the 2014 Morrill Award, which recognizes faculty whose careers have demonstrated excellence in teaching, research, and in engagement missions. He was awarded the BioCrossroads 2013 Watanabe Life Sciences Champion of the Year Award. Dr. Low has received the National Institutes of Health MERIT Award and Purdue's awards for outstanding research and several national and international research awards. His research focuses on targeted therapeutics, fluorescence-guided surgery, techniques for pathogen detection, and the human red blood cell membrane's role in health and disease. For additional information, visit Dr. Low's Purdue website https://www.chem.purdue.edu/activity/public/profile/chem/plow or his Low Research Lab website: http://www.chem.purdue.edu/low/
Categories	Biomedical Engineering Biotechnology Chemistry and Chemical Analysis Medical/Health Pharmaceuticals
Keywords	Acrolein Anti-Inflammatory Antibodies Antimicrobials Autoimmune Disease Biochemistry Biomedical Engineering Biopharmaceutical Manufacturing Biosensors Biotechnology Blood Pressure Cancer Cancer Drug Cancer Research Cancer Therapy Cancer-associated fibroblasts (CAFs) Carbonic anhydrase IX Cell Targeting cell therapy Chemistry and Chemical Analysis Chimeric antigen receptor (CAR) Collagen I conjugate Detection Drug Conjugates Drug Delivery Drug Development Drug Resistance Fibroblast Fibroblast Activation Protein Fibroblast activation protein-alpha Fibroblasts fibrosis Fibrotic Disease Fibrotic Diseases Folate Idiopathic Pulmonary Fibrosis Imaging Immune modulator Immunosuppression immunotherapy Infectious Disease Influenza Inhibitors IPF Ligand-Mediated Targeting Ligand-Targeted Imaging Ligand-Targeted Therapeutics Ligand-targeting Imaging Ligands Macrophages Medical Imaging Medical/Health Medicinal Chemistry Molecular Chemistry Myofibroblast Neuroimaging non-releasable Orthopedics Pain Management Patient Care Pharmaceutical Analysis Pharmaceutical Research Pharmaceuticals Proteins Radiotherapy Regenerative Medicine rejuvenation releasable reprogramming small molecules Solid Cancers Spinal Cord Injury Targeted Immunotherapy targeted therapy Therapeutics Toll like receptor (TLR)