Improved Hydrogels for Cell Culturing and Tissue Engineering

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2023-CLAR-69945
Researchers at Purdue University have developed a method to generate highly-accessible surface reactive sites on hydrogels. These surface sites can participate in thiol-ene click reactions, a broadly used class of reaction chemistry for biofunctionalization. Typically, reactive sites are distributed throughout hydrogels. The Purdue researchers' method creates a high density of reactive sites on the surface, sites which are more readily accessible. The researchers' method involves contacting a polymeric surface material with thiol-functionalized molecules to promote click reactions. The thiol-functionalized molecules can be cell adhesion molecules, allowing the support to be used as an engineered tissue.

Technology Validation: The Purdue researchers' hydrogels have up to 1 reactive site per square nanometer of surface area, whereas typical hydrogels have functionalization densities of 1 reactive site per 1600 cubic nanometer of volume.

Advantages:
High surface density of reactive sites

Applications:
Engineered tissues
Aug 8, 2022
Provisional-Patent
United States
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