COVID-19 Antiviral Compounds

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2022-GHOS-69724
Researchers at Purdue University have developed compounds that inhibit SARS-CoV-2 replication and outperform an approved therapy. Pfizer's Paxlovid and Merck's Molnupiravir are the only antiviral drugs available for individuals with severe COVID-19 symptoms. Purdue researchers are designing more potent compounds to address the continued need for effective COVID-19 therapies. The antiviral drugs developed by the Purdue researchers are 3CLprotease inhibitors that potently block SARS-CoV-2 replication. The best of these compounds are more potent than Pfizer's Paxlovid in enzyme inhibition and antiviral assays. The researchers expect the compounds to have drug-like properties.

Technology Validation: Enzyme inhibition and antiviral assays

Advantages:
- Effective inhibition of 3CLpro enzyme
- Potent antiviral activity

Applications:
- COVID-19 treatment
Feb 7, 2022
Provisional-Gov. Funding
United States
(None)
(None)
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org