Chemical Selective Precision Optical-Control of Biomolecules

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2022-CARL-69575
Researchers at Purdue University have developed a scanning-laser-based technology for real-time precision control of molecular activities and chemical processes in live cells. Current technologies do not allow for automated and selective control of laser-target interactions based on chemical compositions. The Purdue technology automatically detects optical signals from biological molecules to trigger the control laser beam in real-time; the control laser beam is only activated at the pixels when the chemical-selective optical signals are sensed. This technology functions in real-time and effectively controls molecular targets in highly-dynamic living samples. It can be integrated with fluorescence or other types of laser scanning microscopes.

Technology Validation: The technology has diffraction-limited image resolution and opto-control precision (200-500 nm). Chemical-selective signals from fluorescence or Raman can be used to trigger the opto-control laser beam. The response time of the feedback loop is ~20-30 ns.

Advantages
- Fully-automated
- Real-time
- Suitable for living samples
- High chemical selectivity
- Digital logic functions for decision making

Applications
- Microscopy
- Optogenetics
- Controlled release
- Biochemistry
- Cell biology
- Photodynamic therapy
Jan 13, 2022
Provisional-Patent
United States
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Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org