Compounds and Methods for the Selective Rejuvenation of Exhausted CAR T Cells

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NCS: Researchers at Purdue University have discovered a method to rejuvenate exhausted chimeric antigen receptor (CAR) T cells to treat cancers. CAR T cells have shown promise in hematologic cancer treatment, however, their application in eradication of solid tumors remains limited by their development of a dysfunctional or exhausted phenotype, leading to decreased proliferation of CAR T cells and compromised effector function. By targeting ligands of the fluorescein receptor and Toll-like receptor 7/8 (TLR7/8), the Purdue researchers rejuvenated exhausted CAR T cells without harming other cells.

Technology Validation: Systemic administration of fluorescein-TLR7/8 agonist conjugate in vivo not only rejuvenated exhausted CAR T cells in an immunosuppressive tumor microenvironment without stimulating immune cells in healthy tissues, but also halted the growth of CAR T cell-refractory cancers.

-Reverses exhausted CAR T cells
-Effective therapy for CAR T refractory solid tumors

-Solid cancer treatment
Aug 30, 2022

Aug 30, 2021
United States
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