| 2021-SIMP-69445 | |
| Researchers at Purdue University have developed a new spectroscopic technique, fluorescence-detected mid-infrared photothermal microscopy (F-PTIR), that measures chemical compositions of complex biological and pharmaceutical samples in 3D at high spatial resolution. F-PTIR sensitively characterizes highly localized absorption of mid-infrared radiation, exhibiting higher sensitivity than refractive index-based spectroscopies. As an initial proof of concept, the researchers examined a mixture of PEG and hydrated silica gel. F-PTIR effectively discriminates between particles in the mixture and provide clear identification of the composition of individual particles. Further demonstrating the technique's utility, the researchers acquired F-PTIR images of amorphous solid dispersions of the drug ritonavir in copovidone (a soluble polymer) and identified phase-separated domains with enrichment in ritonavir. F-PTIR, which can be readily integrated into existing microscopy platforms, promises to be an important addition to the chemical microscopy and drug development toolkit. Advantages -High Spatial Resolution -Ability to Study Amorphous Solid Dispersions -Highly Sensitive Applications -Spectroscopy -Biological Studies -Pharmaceutical Research and Analysis Technology Validation: The new F-PTIR spectroscopy technique was used for vibrationally-selective chemical imaging of pharmaceutical materials. Recent Publication: "Fluorescence-Detected Mid-Infrared Photothermal Microscopy" Papers with Code, Physics URL: https://physics.paperswithcode.com/paper/fluorescence-detected-mid-infrared |
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Apr 12, 2021
Provisional-Patent
United States
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