Noninvasive Ultra-short Acquisition Delay Magnetic Resonance Spectroscopy Measurement

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2020-EMIR-69079
Researchers at Purdue University have developed a new method for measuring sodium and T2* values in muscles in real-time. In this technique, T2* is measured voxel-wisely at 3T using an accelerated density-weighted concentric ring trajectory (DW-CRT) magnetic resonance spectroscopic imaging (MRSI) device. The algorithms in DW-CRT MRSI account for quantity of nuclei detected with respect to high sampling frequency. Unlike current slice-selective gradient technologies, DW-CRT MRSI uses a non-echo method which prevents time delays and detection limitations. The imaging technique fine-tuned by Purdue researchers can be used to monitor the health of skeletal muscles with improved resolution, reliability, speed, accuracy, and convenience. In addition, DW-CRT MRI can be used to measure the efficacy of therapeutics with ease.

Advantages:
-Reliable
-Fast
-High Resolution Images

Potential Applications:
-Drug Discovery
-MRI

Technology Validation:
Purdue researchers were able to map fast and slow T2* of human calf cells in vivo with minimal sensitivity reduction. The mean of T2* fast was found to be 0.7 +/- 0.1 ms and T2* slow was found to be 13.2 +/- 0.2 ms. The model between T2* corrected voxel-wise and reference concentration result in absolute muscle sodium concentrations 26.3 +/- 3.3 mM.

Recent Publication:
"Density-Weighted Concentric Ring Trajectory using simultaneous multi-band acceleration: 3D metabolite-cycled magnetic resonance spectroscopy imaging at 3T"
Cold Spring Harbor Laboratory
bioRxiv Journal
DOI: 10.1101/628594
May 19, 2020
Provisional-Patent
United States
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Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org