Harnessing Nerve-Muscle Interaction for Accelerating Skeletal Muscle Repair

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Researchers at Purdue University have developed a new approach to skeletal muscle regeneration using nerve cells to promote myoblast response. There remains an unmet need in treating skeletal injuries as implants must be biocompatible to avoid causing adverse effects from presence of a foreign object such as infection and scarring. Purdue researchers introduce a new biomimetic scaffold with a biopolymer matrix containing PC 12 nerve cells that can stimulate nerve function, myoblast behavior, and angiogenesis to promote muscle regeneration. Neural cells are known to contribute to muscle contraction; however, researchers have been able to modulate them for muscle vascularization, regulating stem cell behavior, and regulating cell migration. In testing with human skull cells and nerve cells in vitro, cell aggregation was increased within seven days and high cell viability and metabolic activity were observed.

-Improved Myoblast Behavior
-Self-Renewal of Nerve Cells
-High Cell Viability

Potential Applications:
-Skeletal Muscle Repair & Regeneration
-Advanced Regenerative Biomaterials

Technology Validation:
A new biomimetic scaffolding has been created and has been cultured with nerve cells and skeletal muscle cells to observe cell viability and muscle regeneration behavior.

Recent Publication:
Harnessing Nerve-Muscle Cell Interactions for Biomaterials-Based Skeletal Muscle Regeneration
Journal Biomedical Material Research Part A
DOI: 10.1002/jbm.a.37022
Feb 24, 2021
Utility-Gov. Funding
United States

Apr 28, 2020
Provisional-Gov. Funding
United States
Purdue Office of Technology Commercialization
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Phone: (765) 588-3475
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Email: otcip@prf.org