Discovery of Potent Anti-Mpro Inhibitors for Covid-19 Treatment

Back to all technologies
Download as PDF
2020-GHOS-69034
Researchers at Purdue University have discovered that a potent anti-Mpro inhibitor to be used to treat COVID-19. The anti-Mpro inhibitor is derived from Chloropyridyl ester derivatives. These inhibitors have shown that they have a strong antiviral potency against SARS-COV-2 in VERO cells. VERO cells are a lineage of cell cultures that have been derived from the kidneys of an African green monkey. This inhibitor can block COVID-19 in cell culture assay. This technology can be used to create COVID-19 vaccines. It can also be used in the treatment of COVID-19 patients so that it does not further affect them. This approach is just as effective as Remdesivir, a drug that has shown to help treat patients with COVID-19.

Potential Application:
-Treating Covid-19
-Preventing Covid-19
-Covid-19 Vaccines

Technology Validation: Tested in vero cells.
Feb 9, 2021
PCT-Gov. Funding
WO
(None)
(None)

Dec 1, 2020
Provisional-Gov. Funding
United States
(None)
(None)

Apr 10, 2020
Provisional-Gov. Funding
United States
(None)
(None)
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org