A Lab-on-Chip Platform for Measuring Real-time Nondestructive Extracellular Matrix Stiffness

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2020-RAHI-68964
Researchers at Purdue University have developed a method of in vitro measurement of extracellular matrix (ECM) stiffness that is nondestructive and provides fast readout. ECM stiffness has recently been found to be a contributing factor in cancer or fibrotic disease development including cell differentiation and rapid cell multiplication. Current technologies used to measure ECM stiffness in vitro are often invasive and expensive as well as sometimes limited to detecting cell destruction only after detrimental cell deformations have already occurred. The approach fine-tuned by Purdue researchers is includes a noninvasive on-chip platform that monitors ultrasonic wave attenuation thereby noninvasively characterizing ECM stiffness with up to 93% accuracy. The new low-cost sensors can continuously detect dynamic changes in vitro for up to two days while maintaining thermal stability. The highly selective, biocompatible sensors can also be implemented in applications including drug screening, drug discovery, and 3D cell cultures.

Advantages:
-Low cost
-Nondestructive
-Accurate
-Thermal Stability
-Mechanical Stability

Potential Applications:
-Biomedical
-Research
-3D Cell Cultures
-Drug Screening
-Therapeutic Efficacy Monitoring


Recent Publication:

A Lab-on-Chip Ultrasonic Platform for Real-Time and Nondestructive Assessment of Extracellular Matrix Stiffness
Royal Society of Chemistry's Lab on a Chip Journal
DOI: 10.1039/C9LC00926D
May 13, 2020
Provisional-Gov. Funding
United States
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org