High Throughput Cancer Treatment Screening with Magnetic Actuation Platform

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2019-LEE-68700
Researchers at Purdue University have developed a biomimetic platform using magnetic actuators for in vitro cell seeding. The setup is compatible with multi-well plates and allows for high throughput, thereby reducing the time needed to develop targeted cancer therapies. Cancer treatment screening typically involves use of a synthetic polymer-based substrate, which leads to undesired defects in cell cultures. These polymer substrates are controlled by electromechanical forces that do not accurately replicate natural cell environments. However, Purdue researchers have used magnetic actuators that are adaptable in both amplitude and frequency to apply specific strain that accurately suspends cells over a gap between actuators. In testing with 18,000 cells, within 24 hours a cell culture was ready to be studied. The system allows researchers and medical professionals to capture dynamic physiological conditions in 3D.

Advantages:
-Biomimetic
-Enhanced cancer therapy
-High throughput

Potential Applications:
-Cancer screening
-Microbiology
-Tissue engineering
Jul 22, 2020
Utility Patent
United States
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Jul 23, 2019
Provisional-Patent
United States
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Purdue Office of Technology Commercialization
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Email: otcip@prf.org