Reporter Molecule for Study of Alzheimer's Disease

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Researchers at Purdue University have developed pH-dependent fluorogenic amyloid-beta reporters for the study of Alzheimer's disease (AD). Microglial phagocytosis of amyloid-beta peptides is a critical step in the regulation of brain homeostasis during the initiation and progression of AD. Unlike common methods to study this phenomenon, this technology is specific for amyloid-beta and functions in live cells. The reporter, an isoform of human amyloid-beta tagged with a pH-dependent fluorogenic moiety, fluoresces only upon phagocytosis in the acidic intracellular phagosomes. It clearly differentiates between phagocytic and non-phagocytic cells within live human and nonhuman microglial cells. This technology promises to aid in the discovery of new therapeutics for AD.

-Facilitates live cell tracking of microglial phagocytosis
-Differentiates between phagocytic and non-phagocytic microglial cells

Potential Applications:
-Development of Alzheimer's Therapeutics
Mar 27, 2020

Mar 29, 2019
United States
Purdue Office of Technology Commercialization
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West Lafayette, IN 47906

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