| 2019-YEO-68485 | |
| Researchers at Purdue University have developed a method for encapsulating drugs in liposomes with higher efficiency than competing methods. Liposomal encapsulation of chemotherapeutic agents is widely used to reduce nonspecific side effects, because liposomes will preferentially target the tumor's leaky vasculature. Liposomes are typically loaded with drugs using pH gradients. However, some drugs, such as gemcitabine, a first-line treatment for pancreatic cancer, have proven difficult to load into liposomes with reasonable efficiency. In a proof-of-concept study using this new method, gemcitabine had a loading efficiency of 9.4 - 10.3 wt% compared to 0.14 - 3.8 wt% by conventional methods. Applications for this technology include in the development of novel drug formulations for the treatment of cancer. Advantages: -Higher drug loading efficiency -Good stability and sustained release of drug Potential Applications: -Pharmaceutical formulations Publications: Development of Liposomal Gemcitabine with High Drug Loading Capacity Hassan Tamam, Jinho Park, Hytham H. Gadalla, Andrea R. Masters, Jelan A. Abdel-Aleem, Sayed I. Abdelrahman, Aly A. Abdelrahman, L. Tiffany Lyle, and Yoon Yeo Molecular Pharmaceutics 2019 16 (7), 2858-2871 DOI: 10.1021/acs.molpharmaceut.8b01284 |
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Jul 16, 2021
NATL-Patent
United States
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Jan 16, 2020
PCT-Patent
WO
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Jan 16, 2019
Provisional-Patent
United States
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Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org |
