Liposomal Carriers with High Drug Loading Capacity

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Researchers at Purdue University have developed a method for encapsulating drugs in liposomes with higher efficiency than competing methods. Liposomal encapsulation of chemotherapeutic agents is widely used to reduce nonspecific side effects, because liposomes will preferentially target the tumor's leaky vasculature. Liposomes are typically loaded with drugs using pH gradients. However, some drugs, such as gemcitabine, a first-line treatment for pancreatic cancer, have proven difficult to load into liposomes with reasonable efficiency. In a proof-of-concept study using this new method, gemcitabine had a loading efficiency of 9.4 - 10.3 wt% compared to 0.14 - 3.8 wt% by conventional methods. Applications for this technology include in the development of novel drug formulations for the treatment of cancer.

-Higher drug loading efficiency
-Good stability and sustained release of drug

Potential Applications:
-Pharmaceutical formulations
Jan 16, 2019
United States
Purdue Office of Technology Commercialization
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West Lafayette, IN 47906

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