Clear Optically Matched Panoramic Channel Technique for Deep Brain Photonic Interface

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2019-CUI-68476
Neurophotonics has emerged as the cutting edge tool for study and interface with the brain. A major limitation of neurophotonics is the access depth. Due to the spatially and temporally random light scattering, cellular resolution optical access has been limited to about the thickness of a mouse neocortex. Therefore, the majority of the mouse brain region remains inaccessible, not to mention that of larger mammals. When accessing deep brain regions, we can only view through the tip of the inserted device, similar to viewing through a tunnel.

Researchers at Purdue University have developed COMPACT, or clear optically matched panoramic channel technique, as a way to provide photonic interface with the brain cells deep in the brain, allowing for the deep imaging and control of brain activity. This technology provides a large-volume panoramic view all around the inserted device through the entire length. The adaptability of this technology improves cost because a single imaging probe can be used to view many brains.

Advantages:
-Improvement of access volume by 1000x
-Freedom to choose different regions over a large volume after insertion of device
-Cost-efficient

Potential Applications:
-Head-fixed animal imaging
-Head-mount freely-moving animal imaging
Mar 28, 2020
Utility-Gov. Funding
United States
(None)
(None)

Mar 28, 2020
Provisional-Gov. Funding
United States
(None)
(None)

Mar 28, 2019
Provisional-Gov. Funding
United States
(None)
(None)
Purdue Office of Technology Commercialization
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Email: otcip@prf.org