An Analog of ES2 that is More Potent in Targeting Plant and Fungal EXO70

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Researchers at Purdue University have developed an analog of endosidin2 (ES2) as an inhibitor for suppression of Exo70 proteins in weeds and fungi. Often weeds and fungi become invasive and detrimental to plants, but ES2-based inhibitors can stop their exocytosis process, which in turn halts biosynthesis, growth, and hormone signaling. Purdue researchers have created and compared several ES2 analog inhibitors and discovered that one outperforms the rest. This inhibitor limits fungus growth by a factor of 50% as compared to other ES2 analogs. Analog 14, as it is known, exhibits high sensitivity in selecting Exo70 as its target, which is crucial since proteins in fungi share very similar genetic sequences. In addition, the inhibitor can prevent fungal virulence with superior performance as compared to ES2 alone. Researchers tested the analog 14 inhibitors against traditional fungicide chemicals such as dimethyl sulfoxide (DMSO) in common fungi including rice blast and grey mold fungus, finding that the inhibitor outperforms DMSO by better shortening fungi roots. The ES2 analog inhibitor works within just 60 to 80 minutes on plants. This tool for enhanced farming can be easily implemented as a new fungicide.

-Fast acting
-Inhibits Fungi Growth

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Dec 18, 2019
Utility Patent
United States

Dec 19, 2018
United States
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