Plasmonic Signal Amplification Lateral Flow Sensors

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2019-IRUD-68420
Researchers at Purdue University have developed enhanced lateral flow strips, known as pFLS, by amplifying their plasmonic signals. This technology can be used to detect proteins, whole cells, bacteria, and viruses including E. Coli. The toxin-producing protein E. Coli poses a severe threat to the public as it is commonly found in food items and has shown mortality rates of up to 40%. Current LFS technology such as Enzyme-linked immunosorbent assays (ELISA) often takes hours to get results, is not adapted for practical testing, and requires use of an inconvenient liquid medium for processing. The pLFS device allows for onsite rapid detection, recognizing as low as 100 colony forming units/mL concentration of E. Coli within just 45 minutes — that is 1000 times the sensitivity of traditional LFS and 4 times faster than (ELISA) by comparison. pLFS utilizes a liposome encapsulating reagent to prompt aggregation of gold nanoparticles (GNPs), thereby augmenting colorimetric signals. Researchers have optimized pLFS parameters to ensure reliability and accuracy for food safety.

Advantages:
-Rapid Detection
-Reliable
-Accurate
-High Sensitivity

Potential Applications:
-Food Safety
-Public Health

Publication: Plasmonic enhancement in lateral flow sensors for improved sensing of pathogens.
doi: 10.1016/j.bios.2018.10.066.
Sep 9, 2019
Utility Patent
United States
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Oct 12, 2018
Provisional-Patent
United States
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