High Throughput Nanoelectrospray Ionization Mass Spectrometry

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2018-COOK-68329
Mass spectrometry has many applications including: pharmaceutical development, environmental sampling analysis, and investigative forensics. One growing application of mass spectrometry is high throughput screening is bio-assaying in pharmaceuticals. The lengthy sample pre-treatment in traditional mass spectrometry methods creates a challenging bottleneck for its users.

Researchers at Purdue University have developed an automated high throughput design for nanoelectrospray ionization mass spectrometry (nESI-MS) sample pre-treatment. The pre-treatment time has been reduced from 1 minute in traditional LC-MS to 1.4 seconds for each sample.. This design requires a minimum of 100 nL and can be loaded into a 384 well plate for multiplexed detection. The technology has been used to quantify peptide BACE1 at concentrations as low as 300 nM.

Advantages:
-Faster screening of mass spectrometry samples
-Small volume samples

Potential Applications:
-High throughput mass spectrometry
-Chemical structure analysis
-Bio-assay in pharmaceuticals
May 28, 2020
Utility Patent
United States
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May 31, 2019
Provisional-Patent
United States
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CON-Patent
United States
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Purdue Office of Technology Commercialization
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