High Throughput Nanoelectrospray Ionization Mass Spectrometry

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Mass spectrometry has many applications including: pharmaceutical development, environmental sampling analysis, and investigative forensics. One growing application of mass spectrometry is high throughput screening is bio-assaying in pharmaceuticals. The lengthy sample pre-treatment in traditional mass spectrometry methods creates a challenging bottleneck for its users.

Researchers at Purdue University have developed an automated high throughput design for nanoelectrospray ionization mass spectrometry (nESI-MS) sample pre-treatment. The pre-treatment time has been reduced from 1 minute in traditional LC-MS to 1.4 seconds for each sample.. This design requires a minimum of 100 nL and can be loaded into a 384 well plate for multiplexed detection. The technology has been used to quantify peptide BACE1 at concentrations as low as 300 nM.

-Faster screening of mass spectrometry samples
-Small volume samples

Potential Applications:
-High throughput mass spectrometry
-Chemical structure analysis
-Bio-assay in pharmaceuticals
May 28, 2020
Utility Patent
United States
Oct 5, 2021

Sep 1, 2021
United States

May 31, 2019
United States
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
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Email: otcip@prf.org