Spray Freeze Drying - New Method to Prepare Frozen Particles Allows for Bulk Manufacturing

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2018-ALEX-68290
Researchers at Purdue University have developed an advanced freeze-drying approach for drugs, vaccines, and other biologics. This technology is a spray freeze-drying (SFD) method that can potentially manufacture bulk lyophilized drug products at higher rates compared to conventional freeze-drying in trays and vials. This is due to the fact that small frozen particles have larger surface area available for sublimation. The frozen particles prepared by this method can be used to obtain a flowable, dry powder from a thermally sensitive material such as protein drug product, cell culture, or another material requiring reduced moisture for long-term stability.

Advantages:
-Allows for bulk manufacturing of lyophilized drugs
-Larger surface area available for sublimation
-Reduces moisture for long-term stability

Potential Applications:
-Lyophilized drug products
-Commercial scale SFD equipment
Nov 25, 2018
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United States
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Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org