Frequency Tagging to Record 2D Mass Spectra from Single Ion Populations

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Tandem mass spectrometry (MS/MS) is a method which provides structural information on particular compounds in a mixture after they have been ionized and their characteristic ions have been dissociated to generate product ions. Traditional methods require recording of multiple MS/MS scans which might require the sampling of multiple ion populations to answer questions.

Researchers at Purdue University have developed a methodology for operating a mass spectrometer that extends to the power of MS/MS experiments, providing a new option to rapidly draw conclusions about a sample. This 'frequency tagging' method is particularly valuable for ion traps and miniature in situ mass spectrometers. It provides a rapid way to recognize a sample as belonging to a particular functional group class or containing a component that has particular structural features evident from the product ion spectra.

-Rapidly draw conclusions
-Single linear quadrupole ion trap
-Minimize sample utilization and instrument power

Potential Applications:
-Ion traps
-Miniature instruments
-Multi-analyzer instruments
Apr 9, 2021
United States

Oct 8, 2019

Oct 10, 2018
United States
Purdue Office of Technology Commercialization
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