| 2018-REKL-68230 | |
| Oral solid doses constitute approximately 60% of drug products. Oral solid dose manufacturing must deal with challenges associated with powder rheology; this is problematic for micronized powders which are cohesive. Poorly water-soluble compounds constitute 40% of currently marketed compounds. Particle size reduction is used to improve drug bioavailability, but causes rheological problems in manufacturing. The lack of constitutive equations leads to a demand for an effective precision dosing process. Researchers at Purdue University have developed a new micron-scale powder process. This process enables accuracy dosing of drug mass and low product relative standard deviation; additionally, the method allows for specification of particle size distribution in a product by choice of source material, as experiments have demonstrated that particle size is preserved through the printing process. Advantages: -Versatile processing of fine particles -Low relative standard deviation -Enables production of high-dose pharmaceuticals Potential Applications: -Compounding pharmacy -Slurry printing |
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| (No issued patents found) | |
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