Live Cell Conjugation Chemistry for Imaging, Sensing, Biomanufacturing, and Cell Therapy

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2018-CHOP-68209
Surface modification of live cells has many biomedical and therapeutic applications, such as live cell imaging and cell therapy. The current approaches have limitations including poor stability over time and incompatibility with mammalian cells due to toxicity. There is a need for a new technology that improves surface modification of live cells.

Researchers at Purdue University have developed a new technology that enables surface modification of live mammalian cells. This cell-modification technology has applications in live cell imaging, manufacturing of cell therapies, enhancement of cells for therapeutic applications, cell-drug conjugation for enhanced killing of cancer cells, and drug delivery in a pH dependent manner to sites of inflammation. This technology conjugates small molecules, proteins, fluorophores, and PET tracers to live cells without nanoparticles or other vehicles.


Advantages:
-Conjugation to cell membranes without killing cells
-Functionalizes living cells with components such as small molecules, proteins, fluorophores, and PET tracers
-No use of nanoparticles or other vehicles

Potential Applications:
-Cell membrane imaging
-Enhanced cell therapy
-Production of therapeutic cells
Oct 16, 2020
NATL-Patent
United States
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Apr 17, 2019
PCT-Patent
WO
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Apr 17, 2018
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
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Email: otcip@prf.org