|The most common techniques employed by pharmaceutical companies for the identification of drug metabolites include NMR, IR, and X-ray crystallography. These techniques usually require high-purity samples in large abundance, which require long sample preparation times and are sometimes not feasible due to the instability of some metabolites. Methods for the identification of functionalities such as carboxylic acid, phenol, hydroxyl, amido, amino, N-oxide, sulfone, and sulfoxide have already been developed. The drawback with these methods is that only one reagent can be tested per day, which means only a single functionality can be identified at a time using this system.
Researchers at Purdue University have developed a new pulsed valve inlet system that can introduce up to nine different reagent systems for ion/molecule reactions. This allows for a new method to assist in the structural elucidation of unknown compounds that rapidly identifies metabolites and organic compounds, does not require pure compounds in large abundance, and can be used on unstable metabolites and organic compounds.
-Introduces up to nine different reagents or reagent systems
-Does not require pure compounds in large abundance
-Can be used on unstable metabolites/organic compounds
-Thermo Scientific LTQ mass spectrometer
-Methods for the identification of functionalities
Apr 22, 2020
Apr 22, 2019
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