Inhibitors for Protein alpha-N-terminal Methyltransferases

Back to all technologies
Download as PDF
Protein N-terminal methyltransferase 1 (NTMT1) plays an important role in regulating cell mitosis, chromatin interactions, and DNA repair. NTMT1 is over-expressed in cancer patient tissues including the head and neck, colorectal, malignant melanoma, compared to normal tissue. Knockdown of NTMT1 promotes hypersensitivity of breast cancer cell lines to double-strand DNA breaks (DSBs) by etoposide and gamma irradiation. This knowledge has made NTMT1 an important anticancer target. Currently, there are no specific cell-potent probes available for NTMT1. There is a need for a new technology that can target the NTMT1 protein.

Researchers at Purdue University have developed new potent inhibitors for the protein NTMT. The inhibitor exhibited high selectivity to NTMT1/2 over a panel of 41 methyltransferases. These chemical compounds are novel because they are amenable for cell-based studies. They may be further optimized for animal studies. This technology is more stable and cell-permeable than existing solutions. This technology could open the door for elucidate the pharmacological functions of protein NTMT1.

-Amenable for cell based studies
-Displays selective inhibition for NTMT1
-May be used for animal studies

Potential Applications:
-Cell based studies
-Animal studies
May 16, 2019
Utility Patent
United States

May 17, 2018
United States
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486