Mass Spectrometry Systems and Methods for Conducting Neutral Loss Scans

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2018-COOK-68118
Researchers at Purdue University have developed a computer program to control a table-top mass spectrometer using a linear ion trap. Generally, mass spectrometers are only capable of analyzing the fragments arising from a single precursor ion at a time. By scanning an excitation function and applying simultaneously an ejection waveform at a frequency corresponding to a mass-to-charge ratio (m/z) associated with loss of a neutral fragment, the Purdue researchers' approach allows analysis of multiple ions at once. The approach also minimizes interferences. This technique of waveform generation can open new frontiers in chemical analysis.

Technology Validation: Neutral loss scans connecting two m/z values clearly distinguished four amphetamines from other compounds in a mixture of illicit drugs.

Advantages
- Efficient
- Simple
- Low power

Applications
- Mass spectrometry
- Chemical analysis
- Linear ion traps
Jan 24, 2020
CON-Gov. Funding
United States
10,840,074
Nov 17, 2020

May 21, 2018
Utility Patent
United States
10,580,633
Mar 3, 2020

May 23, 2017
Provisional-Patent
United States
(None)
(None)
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