On-Site Diagnosis of Traumatic Brain Injury

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Track Code	2017-RHOA-67992
Categories	Biomedical Engineering Mechanical Engineering
Keywords	Biomarkers Biomedical Engineering Mechanical Engineering Medical/Health Micro & Nanotechnologies Microresonator Proteins Traumatic Brain Injury
Public Abstract	Microelectromechanical resonators enable sensitive, inexpensive detection of biomarkers, which are indicators of specific diseases, infections, or other medical conditions. However, the detection of s100B, a protein biomarker secreted in the presence of a traumatic brain injury (TBI), is a difficult task to manage. There are numerous methods for identifying biomarkers, but most dependable methods are cumbersome and involve multiple, time-consuming steps that severely limit on-site diagnosis. There is need for a method of detecting biomarkers easily and practically. Researchers at Purdue University have developed a novel functionalization technique that utilizes a piezoelectrically induced resonant microsystem, a promising medical diagnostic tool with high sensitivity. A plate-style resonator is used to sense biomarkers, including s100B, by detecting changes in mass due to biomarkers. The mechanical resonator demonstrates simple, yet powerful sensor functionality. This could be a feasible solution for successfully diagnosing potential TBI victims at the time of injury. Advantages: -Mechanical, label-free sensing -Provides high-sensitivity sensing in a fraction of the time -Portable, can use on-site -Requires only a small amount of fluid for testing -Allows for dry sensing, which is advantageous for single-use/on-site diagnostic applications Potential Applications: -Medical tools for TBI diagnosis Related Publications: -Nikhil Bajaj, et al. Design and Implementation of a Tunable, Duffing-Like Electronic Resonator via Nonlinear Feedback. Journal of Microelectromechanical Systems, Volume 25, Issue 1, February 2016, pp. 2-10. DOI: 10.1109/JMEMS.2015.2493447 -Vijay Kumar, et al. Bifurcation-based mass sensing using piezoelectrically-actuated microcantilevers. Applied Physical Letters, Volume 98, 153510, April 2011. DOI: 10.1063/1.3574920
People	Rhoads, Jeffrey Frederick (Project leader) Bajaj, Nikhil Chiu, George Tsu-Chih Murray, Allison Kelly Nauman, Eric A Tweardy, Mackenzie Wadas, Michael
Intellectual Property	Application Date Jul 19, 2018 Type Utility Patent Country of Filing United States Patent Number 10,948,489 Issue Date Mar 16, 2021 Application Date Feb 10, 2021 Type CON-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Jul 19, 2017 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None)
Contact OTC	Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org