Enhanced Drug Delivery Across Epithelial Barrier

Back to all technologies
Download as PDF
One of the most common practices of drug delivery is by the oral route. However, overcoming the gastrointestinal epithelial barriers is the major challenge for efficient delivery of drugs. Besides the intracellular route or passive diffusion, the paracellular route can be exploited by using a bacterial peptide for enhanced delivery of drugs through the epithelial barrier to reach the underlying lamina propria and submucosal compartment.

Researchers at Purdue University have developed an approach for enhanced delivery of drugs through the intestinal epithelial barrier to reach the underlying propria and submucosal compartment. The use of the Listeria adhesion protein (LAP) enhances permeability through the intestinal barrier. This technology would be suitable for enhanced delivery of a variety of drugs across the mucosal epithelial barrier.

-Enhanced permeability
-Improved efficiency

Potential Applications:
-Drug delivery
-Pharmaceutical companies

Related Publications:
1. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation

2.Crossing the Intestinal Barrier via Listeria Adhesion Protein and Internalin A
Oct 4, 2018
Utility Patent
United States
Apr 28, 2020

Oct 6, 2017
United States
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org