Combination of Cholesterol Esterification Inhibitors with Existing Therapies for Cancer Treatment

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Despite recent advancements in cancer treatment, drug resistance remains a major impediment to developing successful control or cure for cancer. Numerous attempts have been made to decipher the mechanisms underlying cancer resistance, but none have attacked the issue regarding the role cholesterol metabolism plays.

Purdue University researchers found an unexpected accumulation of cholesteryl ester in aggressive types of cancer. Their research has shown that applying an effective amount of at least one agent to an existing cancer treatment resensitizes the cancer cells to the existing cancer treatment by inhibiting cholesterol esterification pathways.

-Targets the metabolic pathway to overcome drug resistance
-Works in conjunction with existing therapies

Potential Applications:
-Cancer treatment
-Drug resistance diseases
Oct 2, 2017

Oct 3, 2016
United States

United States
Purdue Office of Technology Commercialization
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101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486