Muscle Progenitor Cells Enhance Innervation

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Denervation, the loss of nerve supply in muscle fibers, occurs from a variety of causes ranging from serious physical injury to chronic disorders. This disruption in nerve fibers may cause flaccid paralysis, eventually leading to severe muscle atrophy. Following a major injury that results in denervation, the physical muscle tissue may heal, but without an adequate, functioning nervous system connection, no effective physical movement can be made. Research in this area has shown that if the damage is contained to certain nerves, the brain might rewire neurological circuitry and resume somewhat normal function. Unfortunately, in cases of muscle denervation, effective physical muscle movement cannot naturally be reversed.

A Purdue University researcher has developed a toolkit and a method for repairing and reconstructing a damaged or nonfunctional muscle using in vitro primed muscle progenitor cells to promote innervation of the damaged or nonfunctional muscle without any genetic manipulation. Muscle progenitor cells are harvested and grown to a critical mass in culture. The cells are then injected into the damaged or nonfunctional muscle and fuse with native muscle fiber. Following the injection, the muscle is innervated, atrophy has been shown to reverse, and the muscle fibers have an increased force of contraction.

-Does not use genetically modified cells
-Allows the body to naturally regrow nerve connections
-Clinically translatable

Potential Applications
-Muscle repair
-Tissue engineering
Apr 27, 2018
Utility Patent
United States
Feb 1, 2022

Dec 16, 2021
CON-Gov. Funding
United States

Apr 27, 2017
United States
Purdue Office of Technology Commercialization
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