Carrier-Free Nanoparticle Formulation with Good Circulation Stability

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2016-YEO-67581
Researchers at Purdue University have developed a method to produce pharmaceutical nanocrystals comprised of more than 85 percent of their respective active ingredients. These nanocrystals are coated with albumin to prevent the immune response and allow the nanocrystals to target cancerous cells unhindered. These nanocrystals have the potential to increase the effectiveness of a wide range of drugs as they contain a much greater percentage of active ingredients, allow for increased bioavailability, and avoid immune recognition.

Advantages:
-Increases bioavailability of insoluble drugs
-Fewer adverse effects
-Avoids immune recognition

Potential Applications:
-Drug formulation

Related Publications:
J. Park, et al., Albumin-coated nanocrystals for carrier-free delivery of paclitaxel. Journal of Controlled Release (2016). http://dx.doi.org/10.1016/j.jconrel.2016.12.040
Jun 15, 2017
Utility Patent
United States
10,398,651
Sep 3, 2019

Jun 16, 2016
Provisional-Patent
United States
(None)
(None)
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