Adenoviral Vector-Based Influenza Vaccine

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In the past, avian influenza H5N1, H7N7, and H9N2 viruses have infected humans, highlighting the ability of some avian subtypes to cross the species barrier. Such events can cause pandemic outbreaks of influenza by the emergence of an avian-human reassortant virus with the ability to spread rapidly in the human population. Our current therapies have not been effective in abolishing the spread of these diseases. Pandemic influenza viruses, such as H5N1, are less immunogenic compared to epidemic influenza viruses, such as H1N1, and therefore, subunit or inactivated whole virus vaccines for H5N1 do not provide effective protection.

Researchers at Purdue University have developed a novel strategy for combating influenza by using an adenoviral vector-based vaccine delivery system. Adenoviral vectors are known to activate innate immunity and can be administered via the mucosal or parenteral route, resulting in a strong immune rejection response. This novel method has been shown to provide effective protection against a lethal challenge with a pathogenic influenza virus. These vaccine strategies can be easily adapted to either pandemic or epidemic influenza viruses and provide effective protection to the population.

Advantages:
-Provides an effective vaccine for pandemic or epidemic influenza
-Easily mass-produce large quantities of vaccine in a timely manner

Potential Applications:
-Vaccines
Apr 10, 2006
NATL-Patent
European Patent
1877088
Dec 17, 2014

Apr 10, 2006
EP-Patent
United Kingdom
60 2006 044 025.1
Dec 17, 2014

Apr 10, 2006
EP-Patent
Germany
1877088
Dec 17, 2014

Apr 10, 2006
EP-Patent
France
1877088
Dec 17, 2014

Aug 22, 2012
DIV-Patent
Australia
2012-216357
May 15, 2014

Dec 23, 2009
CON-Patent
United States
8,163,545
Apr 24, 2012

Apr 10, 2006
NATL-Patent
Australia
2006236910
Apr 10, 2006

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China
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NATL-Patent
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NATL-Patent
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Provisional-Patent
United States
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Purdue Office of Technology Commercialization
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West Lafayette, IN 47906

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