Diffusion Light Scattering for Nanoparticle Sizing and Biological Assays

Back to all technologies
Download as PDF
Bioconjugated nanoparticles are heavily used in diagnostics and therapeutics, but practical analytical tools for detection and characterization of colloidal solutions are greatly needed. In addition, protein research is an expanding field, but with few tools that allow for high throughput analysis of things such as protein kinetics. These analyses require detection technologies that can image down to the nanometer scale, but a method that operates at high throughput without the need for large samples does not exist.

Researchers at Purdue University have developed a new technology, Diffusion Light Scattering, which is an analyzer that can size nanoparticles and determine the uniformity of the nanoparticle system. This technology allows researchers to size nanoparticles that they either synthesize or functionalized in lab with a mere microscope, eliminating the need for expensive laboratory equipment. Sizing techniques often require large sample volumes, but in both biology and nanotechnology, such large sample sizes are difficult to make; this new analyzer uses smaller sample sizes less than 1 microliter. High throughput real-time analysis of protein binding events, allowing for hundreds of reactions to be studied at the same time is achieved with this analyzer.

-High throughput
-Low sample volumes
-Less expensive
-Easily integrates with existing platforms

Potential Applications:
-Protein research
Jul 25, 2018
United States
Oct 6, 2020

Feb 3, 2017

Feb 5, 2016
United States
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org