Paper Spray Ionization Without Applied Voltage

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2015-COOK-67074
Mass spectrometry (MS) is a powerful analytical technique because of its high sensitivity, selectivity, and speed. Recent progress in MS has depended heavily on advances in methods of ion formation. Creation of stable molecular ions of complex molecules with minimum internal energy has been a primary goal of such experiments. The most widely used methods to achieve this use a high voltage source coupled to the probe to achieve ionization in an ambient environment. The application of high voltage can cause unwanted fragmentation of a target analyte during the ionization process.

Researchers at Purdue University discovered a system configuration that enables paper spray to generate ions for analysis without any voltage source (0 voltage paper spray). Solvent is supplied to a porous material, interacts with a sample within the porous material, and flows to the tip of the porous material. Given a short distance between the tip of the porous material and the inlet of the mass spectrometer, the solvent (now containing one or more analytes of the sample) flows from the porous material into the inlet of the mass spectrometer. Random charging during the breakup of droplets occurs, generating sample ions, which are analyzed within the mass spectrometer. In that manner, systems of the invention generate and analyze ions of a sample without the application of voltage to the porous material.

Advantages:
-Paper spray ionization without applied voltage
-Favorable for certain applications, for example those involving live subjects

Potential Applications:
-Mass spectrometry
-Chemical analysis
Dec 3, 2015
Utility Patent
United States
9,786,478
Oct 10, 2017

Feb 20, 2019
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United States
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Sep 7, 2017
CON-Patent
United States
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Jan 26, 2015
Provisional-Patent
United States
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Dec 5, 2014
Provisional-Patent
United States
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