Recovery of Function In Chronic Spinal Cord Injury

Back to all technologies
Download as PDF
61133
In the United States, there are between 240,000 to 337,000 people chronically injured with severe behavioral loss from spinal cord damage, with approximately 12,500 new cases each year. There is currently no treatment that can recover functions for those affected. Previously, researchers at Purdue University's Center for Paralysis Research have shown 4-aminopyridine (4-AP) to be clinically effective in treating chronic spinal cord injury in both dog and man; the compound is now in phase II human clinical tests.

Purdue University researchers have developed chemical analogues of 4-AP with superior pharmacological properties compared to the parent compound. Special analogues and cocrystals of the compound 4-AP were synthesized and their biological properties were tested. These compounds and all related derivatives and prodrugs dissolve readily at stomach pH facilitating the distribution of the parent compound and the analogues through the body subsequent to oral intake. These drugs (under stomach pH) have been shown to improve nerve impulse conduction through injured spinal cords in in vitro experimental models.

Advantages:
-More effective than 4-AP
-Long-term stability
-Slow dissolution
-Facilitates ease of clinical administration

Potential Applications:
-Medical/Healthcare
-Pharmaceuticals
Dec 5, 2003
NATL-Patent
Canada
2,508,165
May 6, 2014

Jul 16, 2007
DIV-Patent
United States
8,097,638
Jan 17, 2012

Dec 5, 2003
NATL-Patent
Japan
4903385
Jan 13, 2012

Dec 5, 2003
NATL-Patent
Australia
2003298034
Aug 4, 2011

Dec 5, 2003
NATL-Patent
European Patent
1567497
Sep 23, 2009

Dec 5, 2003
EP-Patent
United Kingdom
1567497
Sep 23, 2009

Dec 5, 2003
EP-Patent
France
1567497
Sep 23, 2009

Dec 5, 2003
EP-Patent
Germany
603 29 415.4-08
Sep 23, 2009

Dec 5, 2003
EP-Patent
Ireland
1567497
Sep 23, 2009

Dec 5, 2003
Utility Patent
United States
7,244,748
Jul 17, 2007

May 11, 2005
Provisional-Patent
United States
(None)
(None)

Dec 5, 2003
PCT-Patent
WO
(None)
(None)

Dec 5, 2003
NATL-Patent
New Zealand
(None)
(None)

Dec 5, 2003
NATL-Patent
India
(None)
(None)

Dec 5, 2003
NATL-Patent
China
(None)
(None)

Dec 6, 2002
Provisional-Patent
United States
(None)
(None)

(None)
PCT-Patent
WO
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org