P188 as a Treatment for Trauma to the Nervous System

Back to all technologies

Bookmark/Download	Download as PDF
Track Code	61036
Categories	Biotechnology Medical/Health
Keywords	Biotechnology Central Nervous System Intravenous Medical/Health Nerve Damage Spinal Cord Injury Treatment Methods
Public Abstract	Following mechanical injury to the spinal cord, a large number of sensory and motor nerve fibers are disrupted and subsequently destroyed. The major pathology involved in such nerve loss is related to the breakdown of membranes of nerve cell axons, even to the point of complete severance. Polyethylene glycol (PEG) and other copolymers seal nerve membrane defects and breaches caused by direct mechanical damage. Purdue University researchers have developed a technology that uses poloxamer P188 in spinal cord injury repair applications. P188 can be applied topically to exposed nerve fibers or by intravenous or subcutaneous injection. Similar research has been done with a related polymer, PEG; however, there are several advantages with using P188 in spinal cord injury applications. Advantages: -Can be produced in sterile form -Can be administered by intravenous or subcutaneous injection -Gives identical functional recovery to topically applied PEG Potential Applications: -Medical/Health -Spinal cord injuries
People	Borgens (DECEASED), Richard Ben (Project leader) Lee, Raphael C Shi, Riyi
Intellectual Property	Application Date Jul 28, 2004 Type DIV-Patent Country of Filing United States Patent Number 9,687,502 Issue Date Jun 27, 2017 Application Date Jun 7, 2013 Type CON-Patent Country of Filing United States Patent Number 9,101,655 Issue Date Aug 11, 2015 Application Date Jul 23, 2009 Type CON-Patent Country of Filing United States Patent Number 8,460,646 Issue Date Jun 11, 2013 Application Date Apr 24, 2002 Type NATL-Patent Country of Filing European Patent Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type EP-Patent Country of Filing United Kingdom Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type EP-Patent Country of Filing Germany Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type EP-Patent Country of Filing France Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type EP-Patent Country of Filing Italy Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type EP-Patent Country of Filing Spain Patent Number 1389121 Issue Date Feb 22, 2012 Application Date Apr 24, 2002 Type Utility Patent Country of Filing Canada Patent Number 2,445,612 Issue Date Oct 25, 2011 Application Date Apr 24, 2002 Type Utility Patent Country of Filing United States Patent Number 7,837,987 Issue Date Nov 23, 2010 Application Date Mar 1, 2006 Type DIV-Patent Country of Filing Australia Patent Number 2006200866 Issue Date Feb 21, 2008 Application Date Apr 24, 2002 Type DIV-Patent Country of Filing New Zealand Patent Number 543953 Issue Date Aug 9, 2007 Application Date Apr 24, 2002 Type NATL-Patent Country of Filing New Zealand Patent Number 529526 Issue Date Oct 12, 2006 Application Date Apr 24, 2002 Type Utility Patent Country of Filing Australia Patent Number 2002314758 Issue Date Sep 21, 2006 Application Date May 11, 2011 Type DIV-Patent Country of Filing Canada Patent Number (None) Issue Date (None) Application Date Feb 23, 2009 Type DIV-Patent Country of Filing Japan Patent Number (None) Issue Date (None) Application Date Apr 24, 2002 Type PCT-Patent Country of Filing WO Patent Number (None) Issue Date (None) Application Date Apr 24, 2002 Type Country of Filing Japan Patent Number (None) Issue Date (None) Application Date (None) Type Country of Filing China Patent Number (None) Issue Date (None)
Contact OTC	Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org