Molecular Ionization from Carbon Nanotube Paper Spray

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Track Code	2014-COOK-66769
Categories	Chemistry and Chemical Analysis
Keywords	Analytical Chemistry Chemistry and Chemical Analysis Instrumentation Ion Source Ionization Mass Spectrometry Paper Spray Ionization
Public Abstract	Mass spectrometry is a critical tool that contributes to public health and safety, as well as a multitude of research endeavors, by identifying molecules as diverse as pesticides, toxins, drugs, and biomarkers implicated in human health. Ionization of sample molecules is critical to effective chemical analysis by mass spectrometry. Current ionization technologies often require large, highly sophisticated hardware. In addition, spectra may be compromised by ionization methods that create a variety of ions including fragmented molecules. Researchers at Purdue University, in collaboration with Professor N. Pradeep at the Indian Institute of Technology, Madras, have developed a method of ionization via a carbon nanotube impregnated surface that provides significant advantages to current methods. Samples may be collected by simply wiping the surface across the sample. Ionization is induced by a very small electrical potential. The resulting ionization is gentle on the sample, producing single ion species with no fragment ions. This method has been used to effectively identify pesticides, antibiotics, and amino acids. The small size, simplicity, and effective ionization of this method could easily be incorporated into new spectrometers more suited to portable use. Advantages: -Approximately 1,000 times lower voltage necessary compared to similar ionization methods -Gentle to samples, resulting in less complex spectra -Small, simple, inexpensive design Potential Applications: -Mass spectrometry -Chemical analysis/engineering
People	Cooks, Robert Graham (Project leader) Narayanan, Rahul Pradeep, Thalappil Sarkar, Depanjan
Intellectual Property	Application Date Jan 2, 2020 Type CON-Gov. Funding Country of Filing United States Patent Number 10,991,564 Issue Date Apr 27, 2021 Application Date Aug 23, 2019 Type DIV-Patent Country of Filing Japan Patent Number 6749459 Issue Date Aug 13, 2020 Application Date Jul 19, 2019 Type CON-Patent Country of Filing United States Patent Number 10,559,455 Issue Date Feb 11, 2020 Application Date Dec 22, 2014 Type EP-Patent Country of Filing United Kingdom Patent Number 3089811 Issue Date Nov 6, 2019 Application Date Dec 22, 2014 Type NATL-Patent Country of Filing Japan Patent Number 6,577,950 Issue Date Aug 30, 2019 Application Date Jun 14, 2016 Type NATL-Patent Country of Filing United States Patent Number 10,395,913 Issue Date Aug 27, 2019 Application Date Aug 26, 2016 Type NATL-Patent Country of Filing European Patent Patent Number (None) Issue Date (None) Application Date Aug 26, 2016 Type NATL-Patent Country of Filing China Patent Number (None) Issue Date (None) Application Date Dec 22, 2014 Type PCT-Patent Country of Filing WO Patent Number (None) Issue Date (None) Application Date Dec 22, 2014 Type DIV-Patent Country of Filing Japan Patent Number (None) Issue Date (None) Application Date Jan 13, 2014 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Dec 28, 2013 Type Foreign, Non-PCT Country of Filing India Patent Number (None) Issue Date (None) Application Date (None) Type DIV-Patent Country of Filing Europe Patent Number (None) Issue Date (None)
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