Novel Anticancer Compounds

Back to all technologies
Download as PDF
2014-GHOS-66703
Natural product antitumor compounds, such as FR901464 and spliceostatin A, have particular interest in clinical applications due to their remarkable antitumor activity and effectiveness against human solid tumors. More significantly, both FR901464 and spliceostatin A potently inhibit in vitro splicing and promote pre-mRNA accumulation. The first total synthesis of FR901464 was accomplished in 29-41, which made the original methods time consuming and costly. In addition, it was difficult to produce a pure form of the compound.

Researchers at Purdue University have developed concise, enantioselective syntheses of pure FR901464 and spliceostatin A, which can be accomplished in only 10 and 9 linear steps, respectively. By drastically decreasing the number of steps, this method is cost efficient, convergent, and amenable to the synthesis of structural variants. The researchers have already developed nine synthetic analogues, which are potentially more potent and bioactive, as well as synthesized several other high-quality, natural products such as jasplakinolide and lasonolide A.

Advantages:
-Efficient and cost effective
-Amenable to the synthesis of structural variants

Potential Applications:
-Pharmaceuticals
-Drug development
-Cancer treatment
Jun 14, 2016
NATL-Patent
Australia
2014353087
Nov 1, 2018

May 19, 2016
NATL-Patent
United States
10,000,505
Jun 19, 2018

May 21, 2018
CON-Patent
United States
(None)
(None)

Feb 10, 2017
NATL-Patent
Hong Kong
(None)
(None)

Jun 22, 2016
NATL-Patent
China
(None)
(None)

Jun 20, 2016
NATL-Patent
Indonesia
(None)
(None)

Jun 17, 2016
NATL-Patent
Vietnam
(None)
(None)

Jun 14, 2016
NATL-Patent
New Zealand
(None)
(None)

May 19, 2016
NATL-Patent
Philippines
(None)
(None)

May 19, 2016
NATL-Patent
Singapore
(None)
(None)

May 19, 2016
NATL-Patent
Chile
(None)
(None)

Jan 15, 2016
NATL-Patent
India
(None)
(None)

Nov 19, 2014
PCT-Patent
WO
(None)
(None)

Nov 19, 2014
NATL-Patent
Israel
(None)
(None)

Nov 19, 2014
NATL-Patent
Japan
(None)
(None)

Nov 19, 2014
NATL-Patent
Canada
(None)
(None)

Nov 19, 2014
NATL-Patent
Brazil
(None)
(None)

Nov 19, 2014
NATL-Patent
Peru
(None)
(None)

Nov 19, 2014
NATL-Patent
Mexico
(None)
(None)

Nov 19, 2014
NATL-Patent
Eurasian Patent Organization
(None)
(None)

Nov 19, 2014
NATL-Patent
South Korea
(None)
(None)

Nov 19, 2014
NATL-Patent
South Africa
(None)
(None)

Nov 19, 2014
NATL-Patent
European Patent
(None)
(None)

Nov 19, 2014
NATL-Patent
Colombia
(None)
(None)

Nov 19, 2013
Provisional-Patent
United States
(None)
(None)

(None)
NATL-Patent
Malaysia
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org