Metabolite-Imaging Mass Spectrometry to Guide Brain Surgery

Bookmark/Download	Download as PDF
Track Code	2013-COOK-66578
Categories	Biomedical Engineering
Keywords	Biomedical Engineering Brain Cancer Imaging Mass Spectrometry Medical Imaging Medical/Health Surgical Tools
Public Abstract	Currently, one of the main treatments for brain tumors is surgery. Performing a tumor resection within the brain is difficult because it is not easy to distinguish tumor boundaries from healthy brain tissue. Existing imaging techniques do not provide the necessary molecular information to distinguish tumor boundaries. An unclear boundary between a tumor and healthy tissue can lead to inadequate resection if enough of the tumor remains and neurological damage if healthy tissue is removed. Purdue University researchers have developed a method for surgeons to define tumor margins quickly during surgery using miniature mass spectrometers or separate ionization techniques. This method overcomes the need for prepping, staining, and evaluation by a pathologist. It is also possible to adapt this method for other types of cancer surgery. Advantages: -Overcomes need for prepping, staining, and evaluation by a pathologist -Can be used to determine tumor boundaries Potential Applications: -Medical/Healthcare -Cancer surgery
People	Cooks, Robert Graham (Project leader) Agar, Nathalie Y.R. Dias-Santagata, Dora Dunn, Ian F. Eberlin, Livia Schiavinato Feldman, Daniel R. Gill, Kristen K. Golby, Alexandra J. Ide, Jennifer Jolesz, Ferenc A. Ligon, Keith L. Liu, Xiaohui Norton, Isaiah Orringer, Daniel A. Ramkissoon, Shakti Santagata, Sandro Wiley, Joshua S
Intellectual Property	Application Date Oct 12, 2015 Type CON-Patent Country of Filing United States Patent Number 9,921,233 Issue Date Mar 20, 2018 Application Date Jun 4, 2013 Type CIP-Patent Country of Filing United States Patent Number 9,546,979 Issue Date Jan 17, 2017 Application Date May 18, 2012 Type Utility Patent Country of Filing United States Patent Number 9,157,921 Issue Date Oct 13, 2015 Application Date Jan 17, 2017 Type CON-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Mar 13, 2014 Type Utility Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Mar 15, 2013 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Mar 12, 2013 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date May 18, 2011 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None)
Contact OTC	Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org