Extraction Spray for Direct Mass Spectrometry Analysis of Raw Samples

Back to all technologies
Download as PDF
2013-OUYA-66452
Mass spectrometry is a critical component of modern chemical analysis. Recently, emphasis has been placed on developing mass spectrometry techniques that allow raw samples to be analyzed on-demand. The procedure can be used in many applications such as blood diagnostics for pharmaceutical or illicit drug metabolites and the detection of harmful food additives. Current techniques involve depositing a sample on a paper substrate and eluting the analyte with a fast drying solvent prior to ionization. Some significant problems with this method include inconsistent spray due to the solvent rapidly drying on the paper and low sensitivity on smaller model mass spectrometers because of incomplete analyte solvation.

Researchers at Purdue University have developed a novel device and method of performing mass spectrometry on raw samples. This method combines fast extraction of the analyte from a complex sample matrix on a paper substrate and subsequent spray ionization through a device with consistent spray flow. The consistent flow of sample through this process allows realization of improved sensitivity on a wide variety of mass spectrometers.

Advantages:
-Direct analysis of raw samples
-Improved spray ionization method
-Compatible with a wide variety of mass spectrometers

Potential Applications:
-Mass spectrometry
-Blood diagnostics
-Detection of harmful food additives
Mar 6, 2015
NATL-Patent
United States
10,008,375
Jun 26, 2018

Jan 10, 2014
NATL-Patent
China
ZL201480004002.1
Oct 10, 2017

Jan 10, 2014
PCT-Patent
WO
(None)
(None)

Jan 10, 2014
NATL-Patent
Canada
(None)
(None)

Jan 10, 2014
NATL-Patent
European Patent
(None)
(None)

Mar 13, 2013
Provisional-Patent
United States
(None)
(None)

Jan 31, 2013
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org