Super-Stable Encapsulated Gold Nanorods as Cancer Theranostics

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Gold nanorods (GNR) have potential uses as imaging agents or in cancer treatments because of their ability to be tuned to absorb or scatter various types of light. Gold particles could be injected into the body near a tumor and then heated with a light source to selectively kill the cancer cells. Unfortunately, current fabrication techniques create GNRs that are cytotoxic and breakdown quickly in a saline solution.

To address this, researchers at Purdue University have developed a self-assembly process that encapsulates GNRs into block copolymer micelles. The resultant GNRs are stable against aggregation, even under physiological salt conditions, for indefinite periods of time. This method can be scaled up for mass production and can easily be extended to encapsulate and stabilize other nanoparticle agents.

Advantages:
-Stable for indefinite periods of time
-Can be scaled for mass production
-Encapsulate and stabilize other nanoparticle agents

Potential Applications
-Manufacturing
-Pharmaceuticals
-Medical/Healthcare

Related Publications:
Kim, Dae Hwan, et. al. Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles. ACS Applied Materials & Interfaces. 2012, 4 (4), pp 1872–1877.
DOI: 10.1021/am300198v.
Mar 15, 2013
Utility Patent
United States
9,782,499
Oct 10, 2017

Apr 3, 2012
Provisional-Patent
United States
(None)
(None)
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