|Developing and testing cancer drugs is an expensive process that requires, among other things, exhaustive in vivo animal experiments. One purpose of preclinical animal studies is to analyze how effectively a drug is transported and delivered to its target in a tumor mass. However, animal testing can be an expensive, slow process.
Researchers at Purdue University have developed a microfluidic platform to simulate a 3D tumor vasculature system. This innovative platform can mimic the complex transport processes inside a tumor, such as transvascular transport, interstitial transport, and transmembrane transport. These processes are all simulated on a single benchtop device, thus improving the repeatability and speed of testing, while reducing the cost and use of animals in drug discovery.
-Mimics multiple transport processes
-Increased repeatability and speed for drug testing
Bumsoo Han. Physics-inspired micro/nanotherapeutics: Same problem, different approaches. Molecular Pharmaceutics, July 5, 2016, Vol. 13 (7), pp. 2141-2142. DOI: 10.1021/acs.molpharmaceut.6b00482.
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