Desorption Electrospray Ionization Probe Chemical and Biological Analysis

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Track Code	65914
Categories	Chemistry and Chemical Analysis
Keywords	Chemistry and Chemical Analysis Mass Spectrometry
Public Abstract	Desorption Electrospray Ionization (DESI) is a recently developed ambient ionization technique that can be used in mass spectroscopy (MS) for ambient chemical and biological analysis. DESI is capable of generating ions of analytes in raw samples with no separation and minimal sample preparation. DESI has been applied for tissue imaging, but only in biopsied samples. Researchers at Purdue have developed an ambient DESI probe with the potential to be deployed via catheter for in vivo sampling of biological samples. This probe is directly connected to the mass spectrometer via a length of tube, and the additional length of the tube has been shown to encourage desolvation of droplets and generation of ions for MS analysis. By using water instead of solvent-containing solutions, this device is capable of safely sampling biological surfaces. Advantages: -In vivo sampling -Non-hazardous sampling of biological surfaces Potential Applications: -Chemical Analysis
People	Cooks, Robert Graham (Project leader) Chen, Chien-Hsun Eberlin, Livia Schiavinato Lin, Ziqing Ouyang, Zheng
Intellectual Property	Application Date Oct 9, 2020 Type CON-Gov. Funding Country of Filing United States Patent Number 11,304,637 Issue Date Apr 19, 2022 Application Date Dec 19, 2019 Type CON-Gov. Funding Country of Filing United States Patent Number 10,799,165 Issue Date Oct 13, 2020 Application Date Aug 13, 2019 Type CON-Patent Country of Filing United States Patent Number 10,555,694 Issue Date Feb 11, 2020 Application Date Jan 15, 2019 Type CON-Patent Country of Filing United States Patent Number 10,420,495 Issue Date Sep 24, 2019 Application Date May 25, 2018 Type CON-Patent Country of Filing United States Patent Number 10,213,143 Issue Date Feb 26, 2019 Application Date Jun 8, 2017 Type CON-Patent Country of Filing United States Patent Number 10,004,440 Issue Date Jun 26, 2018 Application Date Jan 6, 2017 Type CON-Patent Country of Filing United States Patent Number 9,700,251 Issue Date Jul 11, 2017 Application Date Apr 16, 2015 Type CON-Patent Country of Filing United States Patent Number 9,538,945 Issue Date Jan 10, 2017 Application Date Jun 1, 2012 Type Utility Patent Country of Filing United States Patent Number 9,024,254 Issue Date May 5, 2015 Application Date Mar 11, 2022 Type CON-Gov. Funding Country of Filing United States Patent Number (None) Issue Date (None) Application Date Jun 3, 2011 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None)
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