Morphologically Friendly Tissue Imaging

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Imaging mass spectrometry is currently in the translational phase as a tool in medical histopathology and offers a capability of mapping drugs, metabolites, lipids, peptides, and proteins without the need for labeling. Currently, a primary limitation preventing good correlational analysis is the use of chemicals that destroy native tissue structures.

Researchers at Purdue University have developed a novel, morphologically friendly method for DESI-MS tissue imaging. The use of processing chemicals that preserve native tissue structures, instead of destroying them, expands the applications of DESI-MS to tissue imaging. DESI-MS has been used in real time to help surgeons decide how much tissue to take during cancer removal procedures. This new morphologically friendly procedure allows a facile means to distinguish between cancerous and healthy tissues.

Advantages:
-Native tissue structure preserved
-Enhanced imaging of complex cancerous tissues

Potential Applications:
-Medical/Healthcare
-Pharmaceuticals
-Medical imaging
Oct 12, 2015
CON-Patent
United States
9,921,233
Mar 20, 2018

Jun 4, 2013
CIP-Patent
United States
9,546,979
Jan 17, 2017

May 18, 2012
Utility Patent
United States
9,157,921
Oct 13, 2015

Feb 8, 2018
CON-Patent
United States
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Mar 13, 2014
Utility Patent
United States
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Mar 15, 2013
Provisional-Patent
United States
(None)
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May 18, 2011
Provisional-Patent
United States
(None)
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Purdue Office of Technology Commercialization
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