Synchronization of Ion Generation

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Track Code	65780
Categories	Chemistry and Chemical Analysis
Keywords	Analytics Chemistry and Chemical Analysis Instrumentation Mass Spectrometry
Public Abstract	Ambient mass spectrometry allows samples to be analyzed in their native state without preparation. Spray-based atmospheric pressure ionization techniques, such as desorption electrospray ionization (DESI) and discontinuous atmospheric pressure introduction (DAPI), ionize samples at ambient pressure. Further improvements to the interface of these systems are needed to increase efficiency of mass spectrometers using ambient sample ionization. Researchers at Purdue University developed a synchronization method that increases the efficiency of spray-based atmospheric pressure ionization sources coupled with miniature mass spectrometers. Synchronized induction shows good performance with over 100-fold improvement in sensitivity, reduced solvent spray flow rate, reduced nebulizing gas usage, 100-fold improvement in sampling efficiency, and quasi-simultaneous recording of positive and negative ion spectra. Advantages: - Increased sampling efficiency - Improved sensitivity - Records negative and positive ion spectra Potential Applications: -Chemical Analysis
People	Cooks, Robert Graham (Project leader) Duncan, Jason S Huang, Guangming Li, Guangtao Li, Xin Sokol, Ewa Yan, Xin
Intellectual Property	Application Date Jan 29, 2019 Type CON-Patent Country of Filing United States Patent Number 10,755,910 Issue Date Aug 25, 2020 Application Date Jan 20, 2012 Type DIV-Patent Country of Filing Japan Patent Number 6,588,118 Issue Date Sep 20, 2019 Application Date Nov 18, 2016 Type CON-Patent Country of Filing United States Patent Number 10,361,073 Issue Date Jul 23, 2019 Application Date Jan 20, 2012 Type DIV-Patent Country of Filing Japan Patent Number 6307572 Issue Date Mar 16, 2018 Application Date Nov 9, 2015 Type CON-Patent Country of Filing United States Patent Number 9,761,426 Issue Date Sep 12, 2017 Application Date Oct 14, 2013 Type CIP-Patent Country of Filing United States Patent Number 9,500,623 Issue Date Nov 22, 2016 Application Date Jan 20, 2012 Type NATL-Patent Country of Filing Japan Patent Number JP6019037 Issue Date Oct 7, 2016 Application Date May 6, 2013 Type CIP-Patent Country of Filing United States Patent Number 9,184,036 Issue Date Nov 10, 2015 Application Date Jul 16, 2020 Type CON-Gov. Funding Country of Filing United States Patent Number (None) Issue Date (None) Application Date Nov 12, 2019 Type DIV-Patent Country of Filing Europe Patent Number (None) Issue Date (None) Application Date Sep 11, 2019 Type DIV-Patent Country of Filing Japan Patent Number (None) Issue Date (None) Application Date Jan 20, 2012 Type PCT-Patent Country of Filing WO Patent Number (None) Issue Date (None) Application Date Jan 20, 2012 Type NATL-Patent Country of Filing European Patent Patent Number (None) Issue Date (None) Application Date Jan 20, 2011 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None)
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