Synchronization of Ion Generation

Back to all technologies
Download as PDF
65780
Ambient mass spectrometry allows samples to be analyzed in their native state without preparation. Spray-based atmospheric pressure ionization techniques, such as desorption electrospray ionization (DESI) and discontinuous atmospheric pressure introduction (DAPI), ionize samples at ambient pressure. Further improvements to the interface of these systems are needed to increase efficiency of mass spectrometers using ambient sample ionization.

Researchers at Purdue University developed a synchronization method that increases the efficiency of spray-based atmospheric pressure ionization sources coupled with miniature mass spectrometers. Synchronized induction shows good performance with over 100-fold improvement in sensitivity, reduced solvent spray flow rate, reduced nebulizing gas usage, 100-fold improvement in sampling efficiency, and quasi-simultaneous recording of positive and negative ion spectra.

Advantages:
- Increased sampling efficiency
- Improved sensitivity
- Records negative and positive ion spectra

Potential Applications:
-Chemical Analysis
Jan 20, 2012
DIV-Patent
Japan
6307572
Mar 16, 2018

Nov 9, 2015
CON-Patent
United States
9,761,426
Sep 12, 2017

Oct 14, 2013
CIP-Patent
United States
9,500,623
Nov 22, 2016

Jan 20, 2012
NATL-Patent
Japan
JP6019037
Oct 7, 2016

May 6, 2013
CIP-Patent
United States
9,184,036
Nov 10, 2015

Jan 29, 2019
CON-Patent
United States
(None)
(None)

Nov 18, 2016
CON-Patent
United States
(None)
(None)

Jan 20, 2012
PCT-Patent
WO
(None)
(None)

Jan 20, 2012
NATL-Patent
European Patent
(None)
(None)

Jan 20, 2012
DIV-Patent
Japan
(None)
(None)

Jan 20, 2011
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org