Internalization of Anticancer Cargo by Bladder Tumor Cells

Back to all technologies
Download as PDF
65688
Bladder cells are well protected and particularly difficult for topically applied therapeutic agents to penetrate. Constant urine influx and periodic voiding of the bladder further limits the effectiveness of therapy. Currently, instillation of live Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is most commonly used to increase penetration of therapeutic agents in the treatment of bladder cancer; however, administration of BCG is associated with high local morbidity and the potential for systemic infection. There is a need for the development of safer, less toxic approaches to administer therapy.

Researchers at Purdue University have developed an effective strategy to promote the internalization of anticancer cargo using the fibronectin attachment protein (FAP) from BCG to gain admittance to bladder tumor cells. FAP binds strongly to targets on the surface of bladder tumor cells; it is subsequently internalized along with the chemotherapeutic cargo. To combat the transitory nature of bladder contents, an antibody-induced microaggregation strategy is employed that promotes rapid internalization of FAP by bladder tumor cells. Furthermore, FAP binding on the surface of bladder tumor cells is resistant to the acidic environment of the bladder. These properties make it an excellent foundation for the design of more effective, less toxic bladder cancer therapies.

Advantages:
-High-affinity targeting of bladder tumor cells
-Rapid internalization
-Binding is resistant to the acidic environment of the bladder

Potential Applications:
-Medical/Healthcare
-Pharmaceuticals
-Drug development
-Biotechnology
Dec 12, 2016
CON-Patent
United States
9,861,707
Jan 9, 2018

May 9, 2013
NATL-Patent
United States
9,518,114
Dec 13, 2016

Nov 11, 2011
PCT-Patent
WO
(None)
(None)

Nov 12, 2010
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org