Detection of Oxidized Proteins for Medical Diagnostics

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Oxidative damage to DNA, RNA, and proteins can seriously threaten the survival of a biological system. High concentrations of radical oxygen species have been implicated in many diseases such as Alzheimer's, Parkinson's, diabetes mellitus, cancer, and a variety of inflammatory diseases. Oxidative stress appears to be caused in part by an organism using iron to carry out oxidative processes. Free radicals, ranging from hydrogen peroxide, singlet oxygen, and peroxynitrite to superoxide, occur widely in cells as part of the assimilation and metabolism of nutrients.

Researchers at Purdue University have developed a diagnostic method for determining the absence or presence of a disease. This method includes assaying the amount and/or type of oxidized peptides in a sample from a subject and comparing them to the amount and types of reference oxidized peptides. For example, using this technique could identify and quantify changes in oxidized peptides or oxidized proteins associated with diseases such as type II diabetes mellitus or breast cancer. This diagnostic method can also be used to monitor a patient's response to a therapeutic agent, e.g., an antioxidant, and monitor disease recurrence. Using the vital information collected with this method, a tailored treatment plan can be created to better aid a patient's recovery.

Advantages:
-Proteomic approach to disease monitoring and diagnosis
-Protein biomarkers detected at low concentrations
-Earlier detection of a large number of diseases
-Non-invasive test

Potential Applications:
-Bioinformatics
-Medical/Healthcare
Aug 27, 2012
NATL-Patent
United States
9,134,318
Sep 15, 2015

Dec 10, 2010
PCT-Patent
WO
(None)
(None)

Dec 10, 2010
NATL-Patent
European Patent
(None)
(None)

Dec 11, 2009
Provisional-Patent
United States
(None)
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Purdue Office of Technology Commercialization
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