Ion Generation by Electrospray Using Wetted Porous Material

Back to all technologies
Download as PDF
65345
Electrospray ionization is regarded as the best characterized and most efficient method for ionization of molecules in solution phase. There are three main stages in the process: droplet formation, droplet evaporation, and ion formation. When a strong electric field is applied, a cone forms and a mist of small droplets is emitted from the tip. This method can produce small, charged droplets under a low flow rate; however, the small size of the tip and the materials used cause problems with the source, which results in the tip easily becoming damaged or clogged. Other methods for overcoming clogging have been developed, but these methods still only work for pure chemicals dissolved in solution.

Purdue University researchers have developed a method that can combine the sample pretreatment and ionization process to reduce the complexity of the device and make it more efficient. This paper method has many benefits that will address the problem of sample introduction in mass analyzers and accelerate the application of miniature spectrometers in situ analysis.

Advantages:
-Few other things required for in situ analysis
-Biological samples can be stored in the precut filter papers for months
-Filter paper minimizes matrix effects and enhances the MS signal of chemicals in complex samples
-Powdered samples can be directly applied to the paper and then analyzed without requiring pretreatment
-Paper can be pretreated to contain internal standards that are released at certain points in quantitative analysis

Potential Applications:
-Chemical Analysis
Apr 29, 2010
NATL-Patent
India
423536
Feb 28, 2023

Oct 18, 2019
DIV-Patent
Europe
EP3633710
Dec 7, 2022

Oct 18, 2019
EP-Patent
United Kingdom
EP3633710
Dec 7, 2022

Oct 18, 2019
EP-Patent
France
EP3633710
Dec 7, 2022

Oct 18, 2019
EP-Patent
Germany
EP3633710
Dec 7, 2022

Jul 23, 2020
CON-Patent
United States
11,287,414
Mar 29, 2022

Nov 21, 2016
CON-Patent
United States
10,761,083
Sep 1, 2020

Apr 29, 2010
NATL-Patent
European Patent
2425448
Dec 4, 2019

Apr 29, 2010
EP-Patent
Germany
2425448
Dec 4, 2019

Apr 29, 2010
EP-Patent
France
2425448
Dec 4, 2019

Apr 29, 2010
EP-Patent
United Kingdom
2425448
Dec 4, 2019

Feb 22, 2018
CON-Patent
United States
10,204,772
Jan 12, 2019

Jan 19, 2016
NATL-Patent
European Patent
3014647
Dec 19, 2018

Apr 29, 2010
NATL-Patent
Canada
2,759,987
Oct 2, 2018

Apr 10, 2017
CON-Patent
United States
9,941,105
Apr 10, 2018

Dec 22, 2015
NATL-Patent
United States
9,620,344
Apr 11, 2017

Mar 4, 2013
CIP-Patent
United States
9,500,572
Nov 22, 2016

Apr 29, 2010
DIV-Patent
Singapore
10201401521U
Nov 2, 2016

Apr 29, 2010
NATL-Patent
China
201080019239.3
Mar 16, 2016

Dec 5, 2014
CON-Patent
United States
9,116,154
Aug 25, 2015

Jan 12, 2015
CON-Patent
United States
9,035,239
May 19, 2015

Sep 9, 2014
CON-Patent
United States
8,937,288
Jan 20, 2015

Sep 12, 2013
CON-Patent
United States
8,933,398
Jan 13, 2015

Apr 29, 2010
NATL-Patent
Japan
5671523
Dec 26, 2014

Dec 26, 2012
CON-Patent
United States
8,890,063
Nov 18, 2014

Jan 9, 2014
CON-Patent
United States
8,859,986
Oct 14, 2014

Dec 26, 2012
CON-Patent
United States
8,859,959
Oct 14, 2014

Dec 26, 2012
CON-Patent
United States
8,859,958
Oct 14, 2014

Jan 31, 2012
Utility Patent
United States
8,859,956
Oct 14, 2014

Apr 29, 2010
NATL-Patent
Australia
2010-0241614
Sep 4, 2014

Sep 11, 2013
CON-Patent
United States
8,816,275
Aug 26, 2014

Nov 26, 2013
Trademark
United States
4,563,866
Jul 8, 2014

May 2, 2014
Trademark
WO
1210100
May 2, 2014

Sep 11, 2013
CON-Patent
United States
8,710,437
Apr 29, 2014

Jun 25, 2013
CIP-Patent
United States
8,704,167
Apr 22, 2014

Apr 29, 2010
NATL-Patent
New Zealand
595809
Jun 3, 2013

Oct 28, 2022
DIV-Patent
Europe
(None)
(None)

Jan 25, 2022
CON-Patent
United States
(None)
(None)

Dec 28, 2018
DIV-Patent
China
(None)
(None)

Apr 21, 2014
PCT-Patent
WO
(None)
(None)

Mar 19, 2014
Trademark
United States
(None)
(None)

Mar 9, 2012
Provisional-Patent
United States
(None)
(None)

Apr 29, 2010
PCT-Patent
WO
(None)
(None)

Apr 29, 2010
NATL-Patent
Singapore
(None)
(None)

Apr 29, 2010
NATL-Patent
South Korea
(None)
(None)

Apr 29, 2010
DIV-Patent
Japan
(None)
(None)

Feb 26, 2010
Provisional-Patent
United States
(None)
(None)

Sep 29, 2009
Provisional-Patent
United States
(None)
(None)

Apr 30, 2009
Provisional-Patent
United States
(None)
(None)

(None)
CON-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org