Ion Generation by Electrospray Using Wetted Porous Material

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Track Code	65345
Categories	Chemical Engineering Chemistry and Chemical Analysis
Keywords	Chemical Engineering Chemistry and Chemical Analysis Mass Spectrometry
Public Abstract	Electrospray ionization is regarded as the best characterized and most efficient method for ionization of molecules in solution phase. There are three main stages in the process: droplet formation, droplet evaporation, and ion formation. When a strong electric field is applied, a cone forms and a mist of small droplets is emitted from the tip. This method can produce small, charged droplets under a low flow rate; however, the small size of the tip and the materials used cause problems with the source, which results in the tip easily becoming damaged or clogged. Other methods for overcoming clogging have been developed, but these methods still only work for pure chemicals dissolved in solution. Purdue University researchers have developed a method that can combine the sample pretreatment and ionization process to reduce the complexity of the device and make it more efficient. This paper method has many benefits that will address the problem of sample introduction in mass analyzers and accelerate the application of miniature spectrometers in situ analysis. Advantages: -Few other things required for in situ analysis -Biological samples can be stored in the precut filter papers for months -Filter paper minimizes matrix effects and enhances the MS signal of chemicals in complex samples -Powdered samples can be directly applied to the paper and then analyzed without requiring pretreatment -Paper can be pretreated to contain internal standards that are released at certain points in quantitative analysis Potential Applications: -Chemical Analysis
People	Cooks, Robert Graham (Project leader) Liu, Jiangjiang Manicke, Nicholas E Ouyang, Zheng Wang, He Yang, Qian
Intellectual Property	Application Date Oct 18, 2019 Type DIV-Patent Country of Filing Europe Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing United Kingdom Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing France Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing Germany Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Jul 23, 2020 Type CON-Patent Country of Filing United States Patent Number 11,287,414 Issue Date Mar 29, 2022 Application Date Nov 21, 2016 Type CON-Patent Country of Filing United States Patent Number 10,761,083 Issue Date Sep 1, 2020 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing European Patent Patent Number 2425448 Issue Date Dec 4, 2019 Application Date Apr 29, 2010 Type EP-Patent Country of Filing Germany Patent Number 2425448 Issue Date Dec 4, 2019 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