Ion Generation by Electrospray Using Wetted Porous Material

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Track Code	65345
Categories	Chemical Engineering Chemistry and Chemical Analysis
Keywords	Chemical Engineering Chemistry and Chemical Analysis Mass Spectrometry
Public Abstract	Electrospray ionization is regarded as the best characterized and most efficient method for ionization of molecules in solution phase. There are three main stages in the process: droplet formation, droplet evaporation, and ion formation. When a strong electric field is applied, a cone forms and a mist of small droplets is emitted from the tip. This method can produce small, charged droplets under a low flow rate; however, the small size of the tip and the materials used cause problems with the source, which results in the tip easily becoming damaged or clogged. Other methods for overcoming clogging have been developed, but these methods still only work for pure chemicals dissolved in solution. Purdue University researchers have developed a method that can combine the sample pretreatment and ionization process to reduce the complexity of the device and make it more efficient. This paper method has many benefits that will address the problem of sample introduction in mass analyzers and accelerate the application of miniature spectrometers in situ analysis. Advantages: -Few other things required for in situ analysis -Biological samples can be stored in the precut filter papers for months -Filter paper minimizes matrix effects and enhances the MS signal of chemicals in complex samples -Powdered samples can be directly applied to the paper and then analyzed without requiring pretreatment -Paper can be pretreated to contain internal standards that are released at certain points in quantitative analysis Potential Applications: -Chemical Analysis
People	Cooks, Robert Graham (Project leader) Liu, Jiangjiang Manicke, Nicholas E Ouyang, Zheng Wang, He Yang, Qian
Intellectual Property	Application Date Apr 29, 2010 Type NATL-Patent Country of Filing India Patent Number 423536 Issue Date Feb 28, 2023 Application Date Oct 18, 2019 Type DIV-Patent Country of Filing Europe Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing United Kingdom Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing France Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Oct 18, 2019 Type EP-Patent Country of Filing Germany Patent Number EP3633710 Issue Date Dec 7, 2022 Application Date Jul 23, 2020 Type CON-Patent Country of Filing United States Patent Number 11,287,414 Issue Date Mar 29, 2022 Application Date Nov 21, 2016 Type CON-Patent Country of Filing United States Patent Number 10,761,083 Issue Date Sep 1, 2020 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing European Patent Patent Number 2425448 Issue Date Dec 4, 2019 Application Date Apr 29, 2010 Type EP-Patent Country of Filing Germany Patent Number 2425448 Issue Date Dec 4, 2019 Application Date Apr 29, 2010 Type EP-Patent Country of Filing France Patent Number 2425448 Issue Date Dec 4, 2019 Application Date Apr 29, 2010 Type EP-Patent Country of Filing United Kingdom Patent Number 2425448 Issue Date Dec 4, 2019 Application Date Feb 22, 2018 Type CON-Patent Country of Filing United States Patent Number 10,204,772 Issue Date Jan 12, 2019 Application Date Jan 19, 2016 Type NATL-Patent Country of Filing European Patent Patent Number 3014647 Issue Date Dec 19, 2018 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing Canada Patent Number 2,759,987 Issue Date Oct 2, 2018 Application Date Apr 10, 2017 Type CON-Patent Country of Filing United States Patent Number 9,941,105 Issue Date Apr 10, 2018 Application Date Dec 22, 2015 Type NATL-Patent Country of Filing United States Patent Number 9,620,344 Issue Date Apr 11, 2017 Application Date Mar 4, 2013 Type CIP-Patent Country of Filing United States Patent Number 9,500,572 Issue Date Nov 22, 2016 Application Date Apr 29, 2010 Type DIV-Patent Country of Filing Singapore Patent Number 10201401521U Issue Date Nov 2, 2016 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing China Patent Number 201080019239.3 Issue Date Mar 16, 2016 Application Date Dec 5, 2014 Type CON-Patent Country of Filing United States Patent Number 9,116,154 Issue Date Aug 25, 2015 Application Date Jan 12, 2015 Type CON-Patent Country of Filing United States Patent Number 9,035,239 Issue Date May 19, 2015 Application Date Sep 9, 2014 Type CON-Patent Country of Filing United States Patent Number 8,937,288 Issue Date Jan 20, 2015 Application Date Sep 12, 2013 Type CON-Patent Country of Filing United States Patent Number 8,933,398 Issue Date Jan 13, 2015 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing Japan Patent Number 5671523 Issue Date Dec 26, 2014 Application Date Dec 26, 2012 Type CON-Patent Country of Filing United States Patent Number 8,890,063 Issue Date Nov 18, 2014 Application Date Jan 9, 2014 Type CON-Patent Country of Filing United States Patent Number 8,859,986 Issue Date Oct 14, 2014 Application Date Dec 26, 2012 Type CON-Patent Country of Filing United States Patent Number 8,859,959 Issue Date Oct 14, 2014 Application Date Dec 26, 2012 Type CON-Patent Country of Filing United States Patent Number 8,859,958 Issue Date Oct 14, 2014 Application Date Jan 31, 2012 Type Utility Patent Country of Filing United States Patent Number 8,859,956 Issue Date Oct 14, 2014 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing Australia Patent Number 2010-0241614 Issue Date Sep 4, 2014 Application Date Sep 11, 2013 Type CON-Patent Country of Filing United States Patent Number 8,816,275 Issue Date Aug 26, 2014 Application Date Nov 26, 2013 Type Trademark Country of Filing United States Patent Number 4,563,866 Issue Date Jul 8, 2014 Application Date May 2, 2014 Type Trademark Country of Filing WO Patent Number 1210100 Issue Date May 2, 2014 Application Date Sep 11, 2013 Type CON-Patent Country of Filing United States Patent Number 8,710,437 Issue Date Apr 29, 2014 Application Date Jun 25, 2013 Type CIP-Patent Country of Filing United States Patent Number 8,704,167 Issue Date Apr 22, 2014 Application Date Apr 29, 2010 Type NATL-Patent Country of Filing New Zealand Patent Number 595809 Issue Date Jun 3, 2013 Application Date Oct 28, 2022 Type DIV-Patent Country of Filing Europe Patent Number (None) Issue Date (None) Application Date Jan 25, 2022 Type CON-Patent Country of Filing United States Patent Number (None) Issue Date (None) Application Date Dec 28, 2018 Type DIV-Patent Country of Filing China Patent Number (None) Issue Date (None) Application Date Apr 21, 2014 Type PCT-Patent Country of Filing WO Patent Number (None) Issue Date (None) Application Date Mar 19, 2014 Type Trademark Country of Filing United States Patent Number 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