Dopamine Receptor Agonists

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Track Code	65304
Categories	Pharmaceuticals
Keywords	Compounds Dopamine Drug Development Medical/Health Parkinson's Disease Pharmaceuticals
Public Abstract	Dopamine is a neurotransmitter that is important in locomotor control, reward circuitry, cognitive function, prolactin release, and a variety of other key physiological functions. Dopaminergic dysfunctions have been implicated in many disorders including Parkinson's disease, schizophrenia, addiction, and ADHD. Dopamine receptor agonists are of interest in terms of finding successful therapies for these disorders. However, current D1 and D2 receptor agonists can have adverse side effects depending on the level and timing of use. Researchers at Purdue University have developed a class of novel D1 dopamine agonists, or stimulants, which may be useful in treating the symptoms of Parkinson's disease and other working memory and cognitive deficits. This series of compounds has potent and selective activity at dopamine D1 receptors, making them useful therapeutic agents in hypodopaminergic conditions. Recent studies have also shown that dopamine D1 agonists are able to reverse drug-induced and age-related deficits in working memory. Advantages: -Novel class of dopamine agonists -Potent and selective activity -Clinical precedent Potential Applications: -Pharmaceutical industry
People	Nichols, David E (Project leader) Watts, Val Joseph
Intellectual Property	Application Date Oct 20, 2011 Type Utility Patent Country of Filing United States Patent Number 9,359,303 Issue Date Jun 7, 2016 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing Japan Patent Number 5734957 Issue Date Apr 24, 2015 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing European Patent Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing United Kingdom Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing Switzerland Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing Ireland Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing Germany Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type NATL-Patent Country of Filing Netherlands Patent Number 2421862 Issue Date Jun 11, 2014 Application Date Apr 21, 2010 Type PCT-Patent Country of Filing WO Patent Number (None) Issue Date (None) Application Date Apr 21, 2009 Type Provisional-Patent Country of Filing United States Patent Number (None) Issue Date (None)
Contact OTC	Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org