Oxygen Generator to Aid Cancer Treatment

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Radiation, surgery, and chemotherapy are the three major treatments for cancer. Radiation destroys cancer cells by using high-energy photons to damage the cell's DNA. The effectiveness of radiation is dependent upon the oxygen concentration in tumors; however, the abnormal structures of tumor vasculature are leaky, lending the tumor environment hypoxic. Hypoxia can impede the success of radiation therapy because oxygen is necessary for successful cancer treatment.

Researchers at Purdue University have developed an ultrasonically powered, implantable micro-oxygen generator that can increase oxygen levels in a tumor target during radiation treatment. The generator has overall dimensions of 1.2mm x 1.3mm x 8mm, so it is small enough to be implanted using a hypodermic needle. This technology performs electrolysis to generate oxygen, which may be able to restore intratumoral oxygen concentrations to a normal or hyperoxygenated level, increasing the effectiveness of cancer treatment outcomes.

Advantages:
-Increases effectiveness of cancer radiation treatments
-Small size allows easy implantation
-Ultrasonically powered using external source

Potential Applications:
-Cancer Treatment
-Pharmaceuticals
-Medical Devices
-Medical/Health
Aug 3, 2011
Utility Patent
United States
9,005,187
Apr 14, 2015

Feb 3, 2010
NATL-Patent
Canada
2,751,454
Aug 6, 2013

Feb 3, 2010
PCT-Patent
WO
(None)
(None)

Feb 3, 2009
Provisional-Patent
United States
(None)
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Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org