65050 | |
Desorption ionization methods are extremely valuable in chemical analysis using mass spectrometry due to their capabilities of generating gas phase analyte ions directly from samples in the condensed phase. Recently developed desorption ionization methods include methods in which the sample is present in the open atmosphere, such as desorption electrospray ionization (DESI), direct analysis in real time (DART), atmospheric pressure dielectric barrier discharge ionization (DBDI), electrospray-assisted laser desorption/ionization (ELDI), and atmospheric-pressure solids analysis probe (ASAP). Some of these methods use active species generated in plasmas for chemical desorption. The gas phase ions formed from the analyte by the active species generated by the low temperature plasma are subsequently mass analyzed by a mass spectrometer. Purdue University researchers have developed a direct current (DC) discharge plasma sustainable with helium at atmospheric pressure for desorption ionization of solids and liquids. An alternating current (AC) direct discharge plasma source has been used for chemical analysis. A plasma pen using pulsed DC has also been developed. In the low temperature plasma probe, a dielectric barrier discharge is used as the plasma source and active species are extracted from the plasma while it is scanned across a surface of interest; at the surface, these active species generate gas phase ions of surface constituents for mass spectrometric analysis. Advantages: -Works with a mini mass spectrometer -Allows for direct analysis of sample Potential Applications: -Chemical analysis |
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Feb 11, 2009
NATL-Patent
European Patent
2,253,009
Aug 28, 2019
Feb 11, 2009
EP-Patent
France
2,253,009
Aug 28, 2019
Feb 11, 2009
EP-Patent
United Kingdom
2,253,009
Aug 28, 2019
Feb 11, 2009
EP-Patent
Germany
2,253,009
Aug 28, 2019
Feb 11, 2009
NATL-Patent
China
ZL 200980104780.1
Nov 25, 2015
May 14, 2013
CON-Patent
United States
9,064,674
Jun 23, 2015
Aug 26, 2013
CON-Patent
United States
8,772,710
Jul 8, 2014
Jul 21, 2010
NATL-Patent
United States
8,519,354
Aug 27, 2013
Feb 11, 2009
PCT-Patent
WO
(None)
(None)
Feb 12, 2008
Provisional-Patent
United States
(None)
(None)
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Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org |