Sensitive Folate Receptor Detection by Immunomagnetic Diffractometry

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Despite the diversity of available malignant disease detection platforms, important challenges still remain in minimizing sensor size, reducing detection time, eliminating target-labeling requirements, minimizing signal amplification steps, and developing simple and inexpensive fabrication protocols.

Researchers at Purdue University have developed an integrated approach for the rapid detection of the folate receptor (FR) using in situ assembled optical diffraction gratings in combination with immunomagnetic capture. With this approach, a detection sensitivity of 700 fM (20 pg/ml) was achieved without any fluorescent or radiolabels or any secondary signal amplification. This approach can be applied to other targets and has the potential to be a broadly applicable, highly sensitive analysis technique.

Advantages:
-Allows early detection of cancer
-Sensitive to femtomolar concentrations
-Simpler assay with lower detection limit compared to current standard

Potential Applications:
-Cancer Detection
-Medical/Healthcare
Nov 25, 2009
NATL-Patent
United States
9,341,621
May 17, 2016

May 29, 2008
PCT-Patent
WO
(None)
(None)

May 31, 2007
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
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